Patient-individual 3D-printing of drugs within a machine-learning assisted closed-loop medication management

A feasibility study

3D-printing of medicines is an innovative manufacturing method that is characterised by a high degree of digitalisation and automation and enables patient-specific care. Its integration into routine healthcare processes is currently challenging due to the requirements of a digital environment.
The aim of our project was to evaluate the integration of a machine-learning assisted 3D printing of medicines into the already existing, fully digital medication process of the hospital (closed-loop medication management, CLMM).

January 2025, 12th edition, The Netherlands

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First, a suitable and clinically relevant active ingredient (levodopa/carbidopa) was identified in a multistep approach by an interdisciplinary panel of experts using defined evaluation criteria, taking into account galenic, clinical and machine learning aspects. In the next step, a formulation using a suitable printing technology for manufacturing a drug according to pharmaceutical quality criteria in different dosages was developed and evaluated for compliance with quality criteria according to the European Pharmacopoeia.

Furthermore, an IT concept was developed and adapted to the hospital’s current IT infrastructure. Likewise, a machine learning algorithm is to be developed to determine the optimal dose for each individual patient using data from smart wearable devices. For this purpose, a clinical trial was set up as a proof-of-principle study for the use of wearables to detect and grade clinical symptoms from Parkinson’s Disease.

Finally, the process is to be connected to the digital medication process (automation) of the hospital taking into account regulatory requirements. Thus, this interdisciplinary feasibility study will provide important insights into the possibilities of integrating patient-specific 3D printing of medicines into everyday clinical practice in the hospital.

A presentation by Adrin Dadkhah, Clinical Pharmacist at University Medical Center Hamburg-Eppendorf.

Adrian is Clinical Pharmacist at the Hospital Pharmacy and Department of Stem Cell Transplantation of the University Medical Center Hamburg-Eppendorf, which was the first hospital in Europe to introduce a fully comprehensive patient record in 2011 and to digitalise and automate the drug supply process.

Adrin Dadkhah will speak at the 2023 edition of the 3D Medical Conference.